Malignant transformation in paget disease of bone
نویسندگان
چکیده
منابع مشابه
Pathology of Paget ’ s disease of bone
Paget’s disease of bone is a common metabolic disorder, which is in most cases diagnosed on the basis of its radiographic findings. Its primary bone alterations and subsequent complications constitute a complex range of pathologic pictures, which may pose diagnostic difficulties upon histologic examination. This article illustrates the spectrum of pathologic features of Paget’s disease of bone ...
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The malignant transformation of conventional giant cell tumor of bone (GCTOB) is rare and usually occurs with irradiation. Here we report two neglected cases of conventional GCTOB with spontaneous malignant transformation at 11 and 16 years after initial diagnosis. In the former case, the patient refused to receive any treatment following the incisional biopsy, and in the latter, the firs...
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Pigmented mammary Paget disease is a very rare clinicopathologic variant of mammary Paget disease. Diagnosis is often difficult because its clinical and histological features are very similar to those of malignant melanoma. Herein, we report a case of pigmented mammary Paget disease misdiagnosed as malignant melanoma.
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The primary objective of Paget’s disease treatment is the relief of symptoms, but treatment is also commonly prescribed to prevent the development of late complications in asymptomatic subjects with active disease (i.e., above normal serum alkaline phosphatase [bALP]). An aggressive course of treatment is recommended before surgery at the site of a pagetic lesion, the aim being to reduce as muc...
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ژورنال
عنوان ژورنال: Cancer
سال: 1992
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19921215)70:12<2802::aid-cncr2820701213>3.0.co;2-n